Journal of Gastrointestinal Oncology 4, 2, 164 - 172 (2013).
Recent advances and significance of intra-arterial infusion chemotherapy in non-resectable colorectal liver metastasis


Atsushi Nanashima , Hiroaki Takeshita , Takafumi Abo , Kazuo Tou , Kenji Tanaka , Daisuke Fukuda , Masaki Kunizaki , Shigekazu Hidaka , Terumitsu Sawai




In era of systemic chemotherapy for colorectal liver metastasis (CLM), role of hepatic intraarterial infusion chemotherapy (HAIC) remains important. We examined treatment effects of HAIC in 36 patients with non-resectable CLM using 5-FU or CPT-11. Tumor response was complete response (CR) in 4, partial response (PR) in 19, stable disease (SD) in 6, and progressive disease (PD) in 7. Tumor control rate was 81% and response rate was 64%. Six patients showed catheter-related complications. Median survival period was 62 months in CR, and 25 with PR. HAIC has a major impact in high chemotherapy response and prolonging survival.