HEPATO-GASTROENTEROLOGY 59, 118, 1964 - 1969 (2012).
Relationship between Microvessel Count and Clinicopathological Characteristics and Postoperative Survival in Patients with Pancreatic Carcinoma


Atsushi Nanashima , Kenichirou Shibata , Toshiyuki Nakayama , Takafumi Abo , Takashi Nonaka , Daisuke Fukuda , Hidetoshi Fukuoka , Shigekazu Hidaka , Hiroaki Takeshita , Terumitsu Sawai , Toru Yasutake , Takeshi Nagayasu




Background/Aims: The present study aimed to elucidate the relationship between microvessel count (MVC) according to CD34 expression and clinicopathlogical characteristics or prognosis in pancreatic carcinoma (PC) patients who underwent hepatectomy. Methodology: CD34 expression was analyzed using immunohistochemical methods. Mean MVC in 5 areas per specimen and clinicopathological factors were consecutively examined in 42 PC patients. Results: Median MVC for PC patients was 123/mm(2), which was applied as a cut-off value. Higher MVC was significantly associated with the advanced Japanese tumor-node-metastasis stage IVa and IVb (p=0.034). Univariate survival analysis identified higher carcinoembryonic antigen (CEA) and CA19-9 level, infiltrative type on macroscopic examination, invasive ductal carcinoma, node metastasis and higher tumor-node-metastasis classification were significantly associated with poor survival. The 5-year overall survival rate in the higher MVC group tended to be lower than that in the higher MVC group (37 vs. 55%), but not statistically significant (p=0.15). Conclusions: Tumor MVC might be a candidate prognostic marker of PC patient survival after pancreatectomy and further investigation in a larger series is warranted to clarify the significance of this marker.