長崎大学大学院 医歯薬学総合研究科 保健学専攻 看護実践科学分野
長崎大学医学部保健学科看護学専攻（基礎・成人・精神・老年看護学領域）
日本語
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English
長崎大学大学院 医歯薬学総合研究科 保健学専攻 看護実践科学分野
長崎大学大学院 医歯薬学総合研究科 保健学専攻 看護実践科学分野
長崎大学医学部保健学科看護学専攻（基礎・成人・精神・老年看護学領域）
長崎大学医学部保健学科看護学専攻（基礎・成人・精神・老年看護学領域）

Publication

  • Publication
  • Clinical Features of Anti-MDA5 Antibody-positive Rapidly Progressive Interstitial Lung Disease without Signs of Dermatomyositis
Internal medicine 58, 6, 837 - 841 (2019)
Clinical Features of Anti-MDA5 Antibody-positive Rapidly Progressive Interstitial Lung Disease without Signs of Dermatomyositis

著者

Noriho Sakamoto , Hiroshi Ishimoto , Shota Nakashima , Hirokazu Yura , Takuto Miyamura , Daisuke Okuno , Atsuko Hara , Takeshi Kitazaki , Tomoyuki Kakugawa , Yuji Ishimatsu , Minoru Satoh , Hiroshi Mukae

カテゴリ

学術論文

Abstract

Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is associated with rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) or dermatomyositis (DM). We herein report three Japanese cases of anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM. High-resolution computed tomography revealed patchy or subpleural distribution of consolidations and/or ground-glass opacities accompanied by traction bronchiectasis. All patients succumbed to respiratory failure within two months. Anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM should be included in the differential diagnosis of acute/subacute ILD. Measurement of anti-MDA5 antibody and an intensive immunosuppressive regimen might rescue these patients from RP-ILD.