長崎大学大学院医歯薬学総合研究科保健学専攻看護実践科学分野（臨床看護学領域）
長崎大学医学部保健学科看護学専攻臨床看護学（基礎・成人看護学領域）
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長崎大学大学院医歯薬学総合研究科保健学専攻看護実践科学分野（臨床看護学領域）
長崎大学大学院医歯薬学総合研究科保健学専攻看護実践科学分野（臨床看護学領域）
長崎大学医学部保健学科看護学専攻臨床看護学（基礎・成人看護学領域）
長崎大学医学部保健学科看護学専攻臨床看護学（基礎・成人看護学領域）

Publication

  • Publication
  • Comparison of Pulmonary Involvement Between Patients Expressing Anti-PL-7 and Anti-Jo-1 Antibodies
LUNG 193, 1, 79 - 83 (2014)
Comparison of Pulmonary Involvement Between Patients Expressing Anti-PL-7 and Anti-Jo-1 Antibodies

著者

Masaomi Tomonaga , Noriho Sakamoto , Yuji Ishimatsu , Tomoyuki Kakugawa , Tatsuhiko Harada , Shota Nakashima , Atsuko Hara , Shintaro Hara , Yoshihiro Horai , Atsushi Kawakami , Hiroshi Mukae , Shigeru Kohno

カテゴリ

学術論文

Abstract

Anti-PL-7 is an anti-tRNA synthetase antibody, and interstitial lung disease (ILD) is the most frequent complication of anti-PL-7-associated antisynthetase syndrome. However, the features of ILD have not been fully elucidated. The present study retrospectively compares 7 and 15 patients who were positive for anti-PL-7 and anti-Jo-1 antibodies, respectively. The features of ILD did not significantly differ between the two groups, but the ratio of lymphocytes in bronchoalveolar lavage fluid was higher in the Jo-1 than in the PL-7 group. High-resolution computed tomography revealed nonspecific interstitial pneumonia in all patients in the PL-7 group and organizing pneumonia in four of the 15 patients in the Jo-1 group. These findings suggest that pulmonary complications slightly differ between patients expressing anti-PL-7 and anti-Jo-1 antibodies. Further studies are required to clarify the features of ILD associated with PL-7.