長崎大学大学院医歯薬学総合研究科保健学専攻看護実践科学分野（臨床看護学領域）
長崎大学医学部保健学科看護学専攻臨床看護学（基礎・成人看護学領域）
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長崎大学大学院医歯薬学総合研究科保健学専攻看護実践科学分野（臨床看護学領域）
長崎大学大学院医歯薬学総合研究科保健学専攻看護実践科学分野（臨床看護学領域）
長崎大学医学部保健学科看護学専攻臨床看護学（基礎・成人看護学領域）
長崎大学医学部保健学科看護学専攻臨床看護学（基礎・成人看護学領域）

Publication

  • Publication
  • A fatal case of acute exacerbation of interstitial lung disease in a patient with rheumatoid arthritis during treatment with tocilizumab
RHEUMATOLOGY INTERNATIONAL 32, 12, 4023 - 4026 (2010)
A fatal case of acute exacerbation of interstitial lung disease in a patient with rheumatoid arthritis during treatment with tocilizumab

著者

Shin-ya Kawashiri , Atsushi Kawakami , Noriho Sakamoto , Yuji Ishimatsu , Katsumi Eguchi

カテゴリ

学術論文

Abstract

A 68-year-old man, who was a patient with established rheumatoid arthritis (RA) with RA-associated interstitial lung disease (RA-ILD) and pulmonary emphysema, began taking tocilizumab. Subsequently, he developed dyspnea parallel to improvement of RA. At 10 months after the administration of tocilizumab, he was urgently admitted because of exacerbation of ILD. He died despite receiving steroid pulse therapy and antibiotic therapy on a respirator. This is the first case report to describe the exacerbation of ILD during treatment with tocilizumab in the postmarketing surveillance (PMS) period.