長崎大学大学院 医歯薬学総合研究科 保健学専攻 看護実践科学分野
長崎大学医学部保健学科看護学専攻（基礎・成人・精神・老年看護学領域）
日本語
|
English
長崎大学大学院 医歯薬学総合研究科 保健学専攻 看護実践科学分野
長崎大学大学院 医歯薬学総合研究科 保健学専攻 看護実践科学分野
長崎大学医学部保健学科看護学専攻（基礎・成人・精神・老年看護学領域）
長崎大学医学部保健学科看護学専攻（基礎・成人・精神・老年看護学領域）

Publication

  • Publication
  • Diffuse Alveolar Hemorrhage following Itraconazole Injection
INTERNAL MEDICINE 49, 5, 497 - 500 (2010)
Diffuse Alveolar Hemorrhage following Itraconazole Injection

著者

Koichi Izumikawa , Ken Nakano , Shintaro Kurihara , Yoshifumi Imamura , Kazuko Yamamoto , Taiga Miyazaki , Noriho Sakamoto , Masafumi Seki , Yuji Ishimatsu , Hiroshi Kakeya , Yoshihiro Yamamoto , Katsunori Yanagihara , Tomoshi Tsuchiya , Naoya Yamasaki , Tsutomu Tagawa , Hiroshi Mukae , Takeshi Nagayasu , Shigeru Kohno

カテゴリ

学術論文

Abstract

Diffuse alveolar hemorrhage (DAH) syndrome is potentially fatal. We encountered a nearly fatal case of DAH possibly due to intravenous itraconazole (ITCZ). A 53-year-old man with chronic pulmonary aspergillosis underwent pneumonectomy of the left lung 15 days prior to the onset of DAH, which was confirmed by bronchoalveloar lavage. The battery of diagnostic evaluations performed revealed no other positive etiological factor, leading to the diagnosis of DAH possibly induced by intravenous ITCZ with a positive drug lymphocyte stimulation test. The patient did not respond to pulse methylprednisolone therapy, but responded dramatically to direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX) therapy.